Stadium: Levi's Stadium Round: 11
Home Manager: Mike Macdonald Away Manager: Kyle Shanahan
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 3 | 6 | 7 | 7 | 20 |
| 7 | 0 | 7 | 3 | 7 | 17 |
| SEA Seahawks | SF 49ers |
| Lineup | |
|---|---|
| 16 - WR - Tyler Lockett | Evan Anderson - DL - 69 |
| 21 - Center back - Devon Witherspoon | Jake Moody - K - 4 |
| 11 - WR - Jaxon Smith-Njigba | Spencer Burford - OL - 74 |
| 88 - TE - AJ Barner | Jordan Mason - Right back - 24 |
| 5 - K - Jason Myers | Isaac Guerendo - Right back - 31 |
| 32 - SAF - Jerrick Reed | Brayden Willis - FB - 9 |
| 91 - DT - Byron Murphy | Brock Purdy - QB - 13 |
| 65 - T - Michael Jerrell | Aaron Banks - OG - 65 |
| 70 - OG - Laken Tomlinson | Robert Beal Jr. - Left back - 51 |
| 1 - WR - Laviska Shenault Jr. | Jake Tonges - TE - 88 |
| 7 - QB - Geno Smith | Nick Zakelj - OL - 63 |
| 13 - Left back - Ernest Jones | Kalia Davis - DL - 93 |
| 29 - DB - Josh Jobe | Isaac Yiadom - DB - 22 |
| 48 - Left back - Tyrice Knight | Renardo Green - DB - |
| 99 - DE - Leonard Williams | Dee Winters - Left back - 53 |
| 33 - DB - Dee Williams | Ricky Pearsall - WR - 1 |
| 82 - WR - Cody White | Dominick Puni - OL - 77 |
| 97 - DL - Johnathan Hankins | Deommodore Lenoir - DB - 2 |
| 22 - Center back - Tre Brown | Nick McCloud - Center back - 35 |
| 67 - OL - Charles Cross | Jaylon Moore - OL - 76 |
| 94 - DE - Mike Morris | Jordan Elliott - DT - 92 |
| 18 - Left back - Josh Ross | Colton McKivitz - OL - 68 |
| 27 - Center back - Tariq Woolen | Yetur Gross-Matos - DE - 94 |
| 64 - DB - Christian Haynes | Malik Mustapha - DB - 6 |
| 41 - - Chris Stoll | Ji'Ayir Brown - SAF - 27 |
| 20 - Center back - Julian Love | Sam Okuayinonu - DT - 91 |
| 72 - OL - Abraham Lucas | Jacob Cowing - WR - 19 |
| 8 - Center back - Coby Bryant | Tatum Bethune - Left back - 48 |
| 39 - SS - Ty Okada | Jauan Jennings - WR - 15 |
| 53 - DL - Boye Mafe | Nick Bosa - DL - 97 |
| 55 - DL - Dre'Mont Jones | Deebo Samuel - WR - 1 |
| 14 - WR - DK Metcalf | Tashaun Gipson - SAF - 43 |
| 19 - WR - Jake Bobo | George Odum - OLB - 30 |
| 85 - TE - Tyler Mabry | Eric Saubert - TE - 82 |
| 86 - TE - Pharaoh Brown | Christian McCaffrey - Right back - 23 |
| 26 - Right back - Zach Charbonnet | Taybor Pepper - LS - 46 |
| 75 - Guard - Anthony Bradford | Jake Brendel - OL - 64 |
| 52 - DT - Patrick O'Connell | Chris Conley - WR - 18 |
| 25 - Right back - Kenny McIntosh | Leonard Floyd - Left back - 56 |
| 58 - OLB - Derick Hall | De'Vondre Campbell - Left back - 59 |
| 9 - Right back - Kenneth Walker III | Maliek Collins - DT - 99 |
| 42 - Left back - Drake Thomas | Trent Williams - OL - 71 |
| 98 - DL - Roy Robertson-Harris | Rock Ya-Sin - Center back - 33 |
| 55 - Center - Olusegun Oluwatimi | Kyle Juszczyk - FB - 44 |
| 90 - DL - Jarran Reed | Fred Warner - Left back - 54 |
| 61 - Center - Jalen Sundell | Pat O'Donnell - Pivot - 40 |
| 4 - Pivot - Michael Dickson | Demetrius Flannigan-Fowles - SAF - 45 |
| Substitutes | |