Stadium: Reed Green Coliseum Round: 1
Home Manager: Joye Lee-McNelis Away Manager: Ashley Walker-Johnson
| WNCAAB | 2018/03/07 17:00 | UTEP (W) v Southern Miss (W) | L | 72-67 |
| WNCAAB | 2018/03/03 20:00 | Southern Miss (W) v Florida Intl (W) | L | 70-74 |
| WNCAAB | 2018/03/02 00:00 | Southern Miss (W) v Western Kentucky (W) | W | 69-63 |
| WNCAAB | 2018/02/25 20:00 | Southern Miss (W) v UTEP (W) | W | 60-53 |
| WNCAAB | 2018/02/24 00:00 | Southern Miss (W) v Florida Atlantic (W) | L | 74-89 |
| WNCAAB | 2018/02/17 20:30 | Louisiana Tech (W) v Southern Miss (W) | L | 89-57 |
| WNCAAB | 2018/02/15 23:00 | North Texas (W) v Southern Miss (W) | L | 71-62 |
| WNCAAB | 2018/02/10 20:00 | Southern Miss (W) v Old Dominion (W) | L | 55-74 |
| WNCAAB | 2018/03/03 23:00 | Arkansas Pine Bluff (W) v Mississippi Valley State (W) | L | 79-64 |
| WNCAAB | 2018/02/26 23:30 | Grambling State (W) v Mississippi Valley State (W) | L | 64-55 |
| WNCAAB | 2018/02/24 23:30 | Jackson State (W) v Mississippi Valley State (W) | L | 68-67 |
| WNCAAB | 2018/02/19 23:30 | Mississippi Valley State (W) v Prairie View A&M (W) | L | 74-75 |
| WNCAAB | 2018/02/17 20:00 | Mississippi Valley State (W) v Texas Southern (W) | L | 53-72 |
| WNCAAB | 2018/02/12 20:00 | Southern (W) v Mississippi Valley State (W) | L | 66-58 |
| WNCAAB | 2018/02/10 21:00 | Alcorn State (W) v Mississippi Valley State (W) | W | 61-62 |
| WNCAAB | 2018/02/05 23:30 | Mississippi Valley State (W) v Alabama A&M (W) | L | 49-57 |