Stadium: Mott Athletics Center
Home Manager: Heidi VanDerveer Away Manager: Faith Mimnaugh
| WNCAAB | 2021/01/02 23:00 | UC San Diego (W) v Cal Poly SLO (W) | W | 74-63 |
| WNCAAB | 2021/01/01 23:00 | UC San Diego (W) v Cal Poly SLO (W) | L | 68-90 |
| WNCAAB | 2021/03/07 01:00 | Cal State Fullerton (W) v UC San Diego (W) | W | 66-68 |
| WNCAAB | 2021/03/06 01:00 | Cal State Fullerton (W) v UC San Diego (W) | L | 60-57 |
| WNCAAB | 2021/02/28 01:00 | UC Irvine (W) v UC San Diego (W) | L | 64-58 |
| WNCAAB | 2021/02/27 01:00 | UC San Diego (W) v UC Irvine (W) | W | 66-63 |
| WNCAAB | 2021/02/21 00:00 | UC Riverside Women v UC San Diego (W) | W | 67-74 |
| WNCAAB | 2021/02/20 00:00 | UC Riverside Women v UC San Diego (W) | W | 59-63 |
| WNCAAB | 2021/02/14 01:00 | UC San Diego (W) v Cal State Bakersfield (W) | L | 66-69 |
| WNCAAB | 2021/02/13 01:00 | UC San Diego (W) v Cal State Bakersfield (W) | L | 38-62 |
| WNCAAB | 2021/03/12 23:00 | Cal Poly SLO (W) v UC Irvine (W) | L | 59-68 |
| WNCAAB | 2021/03/11 04:00 | Cal Poly SLO (W) v Long Beach State (W) | W | 61-60 |
| WNCAAB | 2021/03/06 22:00 | UC Santa Barbara (W) v Cal Poly SLO (W) | L | 78-68 |
| WNCAAB | 2021/03/05 22:00 | Cal Poly SLO (W) v UC Santa Barbara (W) | W | 76-46 |
| WNCAAB | 2021/02/27 23:00 | Cal Poly SLO (W) v UC Davis (W) | L | 53-62 |
| WNCAAB | 2021/02/26 23:00 | UC Davis (W) v Cal Poly SLO (W) | L | 63-47 |
| WNCAAB | 2021/02/20 22:00 | Cal Poly SLO (W) v Long Beach State (W) | W | 45-42 |
| WNCAAB | 2021/02/19 22:00 | Long Beach State (W) v Cal Poly SLO (W) | W | 44-55 |